• Email Us: [email protected]
  • Contact Us: +1 718 874 1545
  • Skip to main content
  • Skip to primary sidebar

Medical Market Report

  • Home
  • All Reports
  • About Us
  • Contact Us

How “Zombie” Cells Could Be The Answer To Shortage Of Donor Hearts

June 5, 2023 by Deborah Bloomfield

A test that can quickly identify so-called “zombie” cells in potential donor hearts could mean more of these much-needed organs being available for transplantation. Currently, in the UK, hearts from over-65s are not accepted due to the likelihood of a poor outcome for the transplant recipient, but in some cases this cautious approach could be leading to healthy organs being refused.

“Zombie” cells, as the name suggests, are not quite dead, but are also not in tip-top condition. Horror fans will know the risks zombies pose to healthy, un-zombified humans – the usual trope involves them biting or otherwise infecting other people to turn them into fellow ambulatory corpses. So it is with the “zombie” cells: they release harmful molecules that turn neighboring cells into “zombies” too.

Advertisement

On top of this, “zombie” cells increase the risk of heart and circulatory diseases, and cause inflammation and scarring of the heart muscle. People who already have heart disease – and this is more common in older people – are known to have higher levels of these cells. 

It’s pretty clear to see why a heart from someone with a lot of “zombie” cells wouldn’t be suitable for transplantation, but not all older people have biologically unhealthy hearts. The problem is that it’s very difficult to tell either way, which is why researchers are hoping to develop a test that would be able to detect a “zombie” cell signature in the blood.

“Our work is revealing more about the clues that ‘zombie’ cells leave to suggest their presence in the body. We are confident that we will be able to use these clues to better understand which hearts from non-eligible donors might be able to be used after all,” said lead researcher Dr Gavin Richardson of Newcastle University, in a statement. 

“This could be a game changer – as currently most hearts from older donors are not used for transplant, but the hope is we will be able to show that a number of these organs are suitable for transplant for people desperately waiting for a new heart.”

Advertisement

The study authors took blood samples from 774 individuals over the age of 85, to investigate what proteins and other markers might make up a detectable “zombie” cell signature. They found increased levels of a protein called GDF15 in the blood of those who had heart disease, compared with those who did not. This increase followed a similar pattern to that of another protein already used by clinicians to diagnose heart failure, so the team was confident that they were on the right track.

They then examined the RNA in cells from eight donor hearts, specifically a marker called p21. Again, they found strong links between this and another marker that is already known to be an indicator of heart disease.

The researchers think that both GDF15 and p21 will be important components of the “zombie” cell signature they’re trying to characterize. The next phase of the study involves looking for this signature in blood and tissue samples from previously donated organs, to see if there’s any link with transplant success. 

In the UK alone, there are currently around 320 people waiting for a life-saving heart transplant. Research like this could mean that more organs become eligible for use.

Advertisement

“For many reasons, hearts from donors of any age are often not suitable for transplant,” explained Derek Manas, Medical Director for Transplantation at NHS Blood and Transplant. “We are keen to support any research which may help us increase the number of hearts suitable for transplantation, save more lives and improve outcomes for those who are waiting.”

The study was presented at the 2023 British Cardiovascular Society Annual Conference.

Deborah Bloomfield
Deborah Bloomfield

Related posts:

  1. Tennis-Scrappy Sakkari survives gruelling three-setter to beat Andreescu
  2. Cricket-NZ players reach Dubai after ‘specific, credible threat’ derailed Pakistan tour
  3. Accel, Tiger and Stripe’s COO back Mexico City-based Higo as it raises $23M for its B2B payments platform
  4. The Cat Flap Is Surprisingly Ancient, And Not The Work Of Isaac Newton

Source Link: How “Zombie” Cells Could Be The Answer To Shortage Of Donor Hearts

Filed Under: News

Primary Sidebar

  • Unethical Experiments: When Scientists Really Should Have Stopped What They Were Doing Immediately
  • The First Humans Were Hunted By Leopards And Weren’t The Apex Predators We Thought They Were
  • Earth’s Passage Through The Galaxy Might Be Written In Its Rocks
  • What Is An Einstein Cross – And Why Is The Latest One Such A Unique Find?
  • If We Found Life On Mars, What Would That Mean For The Fermi Paradox And The Great Filter?
  • The Longest Living Mammals Are Giants That Live Up To 200 Years In The Icy Arctic
  • Entirely New Virus Detected In Bat Urine, And It’s Only The 4th Of Its Kind Ever Isolated
  • The First Ever Full Asteroid History: From Its Doomed Discovery To Collecting Its Meteorites
  • World’s Oldest Pachycephalosaur Fossil Pushes Back These Dinosaurs’ Emergence By 15 Million Years
  • The Hole In The Ozone Layer Is Healing And On Track For Full Recovery In The 21st Century, Thanks To Science
  • First Sweet Potato Genome Reveals They’re Hybrids With A Puzzling Past And 6 Sets Of Chromosomes
  • Why Is The Top Of Canada So Sparsely Populated? Meet The “Canadian Shield”
  • Humans Are In The Middle Of “A Great Evolutionary Transition”, New Paper Claims
  • Why Do Some Toilets Have Two Flush Buttons?
  • 130-Year-Old Butter Additive Discovered In Danish Basement Contains Bacteria From The 1890s
  • Prehistoric Humans Made Necklaces From Marine Mollusk Fossils 20,000 Years Ago
  • Zond 5: In 1968 Two Soviet Steppe Tortoises Beat Humans To Orbiting Around The Moon
  • Why Cats Adapted This Defense Mechanism From Snakes
  • Mother Orca Seen Carrying Dead Calf Once Again On Washington Coast
  • A Busy Spider Season Is Brewing: Why This Fall Could See A Boom Of Arachnid Activity
  • Business
  • Health
  • News
  • Science
  • Technology
  • +1 718 874 1545
  • +91 78878 22626
  • [email protected]
Office Address
Prudour Pvt. Ltd. 420 Lexington Avenue Suite 300 New York City, NY 10170.

Powered by Prudour Network

Copyrights © 2025 · Medical Market Report. All Rights Reserved.

Go to mobile version