• Email Us: [email protected]
  • Contact Us: +1 718 874 1545
  • Skip to main content
  • Skip to primary sidebar

Medical Market Report

  • Home
  • All Reports
  • About Us
  • Contact Us

Newly Approved Schizophrenia Drug Could Eventually Treat Alzeimer’s-Related Psychosis

December 3, 2024 by Deborah Bloomfield

A drug that has recently been approved for the treatment of schizophrenia could one day be prescribed to Alzheimer’s patients. Researchers are trialing Cobenfy to see if it effectively treats Alzheimer’s-induced psychosis. However, there is still a fair way to go before we see if it will be approved as a treatment option for this particular condition. 

Cobenfy was approved for use in the treatment of schizophrenia by the US Food and Drug Administration (FDA) in late September. There has been a great deal of hype around the drug, which has been described as “the first new approach” to the treatment of schizophrenia in decades.   

Advertisement

Technically, it is not one but two drugs: Xanomeline and Trospium. Xanomeline was first developed in the 1990s and trialed in patients with Alzheimer’s disease, appearing to improve cognitive function and lower psychotic symptoms. However, it also triggered several nasty side effects in many patients, including nausea and vomiting, which led to it being shelved – at least, temporarily. Trospium is a muscarinic receptor-blocking drug that can’t traverse the blood-brain barrier, so the addition of that drug to the mix reduces the unpleasant side effects in the body.

Cobenfy has created a lot of excitement because it applies a new mechanism to treat schizophrenia – it targets muscarinic acetylcholine receptors, found in cell membranes. In particular, it targets two of these receptors: M4 and M1.

While Alzheimer’s and schizophrenia are completely different diseases, there are overlapping symptoms such as paranoia, and over half of those with Alzheimer’s will go on to develop psychotic symptoms. 

Cobenfy was first developed by Karuna Therapeutics, a company that has been bought by the New Jersey pharmaceutical company Bristol Myers Squibb (BMS). The company is currently running trials to see if the drug would benefit those experiencing psychosis as a result of Alzheimer’s. 

Advertisement

According to BioPharma Dive, the company is planning to begin late-stage testing next. In 2026, they project to have collected the results from two trials involving a combination of around 800 people who have psychosis caused by Alzheimer’s. According to PharmaVoice, if successful, it is thought the drug could make even more sales from Alzheimer’s patients than those with schizophrenia. 

The Alzheimer’s Association estimates 6.9 people in the US have Alzheimer’s. It is an extremely complex condition and there is currently no cure. However, researchers have recently announced exciting new developments that could pave the way for better treatments in the future, from novel theories that may change the way we think of the disease to new treatment options, including drugs and genetic therapy.

[H/t Nature.]

Deborah Bloomfield
Deborah Bloomfield

Related posts:

  1. No ‘magic wand’ to fix Lebanon crisis, new prime minister says
  2. Looking For A New Career In Tech? Get This CompTIA Training.
  3. Parker Solar Probe Finds The Source Of Fast Solar Wind Flurries
  4. Why Do Animals Have Different Pupil Shapes?

Source Link: Newly Approved Schizophrenia Drug Could Eventually Treat Alzeimer’s-Related Psychosis

Filed Under: News

Primary Sidebar

  • Martian Mudstone Has Features That Might Be Biosignatures, New Brain Implant Can Decode Your Internal Monologue, And Much More This Week
  • Crocodiles Weren’t All Blood-Thirsty Killers, Some Evolved To Be Plant-Eating Vegetarians
  • Stratospheric Warming Event May Be Unfolding In The Southern Polar Vortex, Shaking Up Global Weather Systems
  • 15 Years Ago, Bees In Brooklyn Appeared Red After Snacking Where They Shouldn’t
  • Carnian Pluvial Event: It Rained For 2 Million Years — And It Changed Planet Earth Forever
  • There’s Volcanic Unrest At The Campi Flegrei Caldera – Here’s What We Know
  • The “Rumpelstiltskin Effect”: When Just Getting A Diagnosis Is Enough To Start The Healing
  • In 1962, A Boy Found A Radioactive Capsule And Brought It Inside His House — With Tragic Results
  • This Cute Creature Has One Of The Largest Genomes Of Any Mammal, With 114 Chromosomes
  • Little Air And Dramatic Evolutionary Changes Await Future Humans On Mars
  • “Black Hole Stars” Might Solve Unexplained JWST Discovery
  • Pretty In Purple: Why Do Some Otters Have Purple Teeth And Bones? It’s All Down To Their Spiky Diets
  • The World’s Largest Carnivoran Is A 3,600-Kilogram Giant That Weighs More Than Your Car
  • Devastating “Rogue Waves” Finally Have An Explanation
  • Meet The “Masked Seducer”, A Unique Bat With A Never-Before-Seen Courtship Display
  • Alaska’s Salmon River Is Turning Orange – And It’s A Stark Warning
  • Meet The Heaviest Jelly In The Seas, Weighing Over Twice As Much As A Grand Piano
  • For The First Time, We’ve Found Evidence Climate Change Is Attracting Invasive Species To Canadian Arctic
  • What Are Microfiber Cloths, And How Do They Clean So Well?
  • Stowaway Rat That Hopped On A Flight From Miami Was A “Wake-Up Call” For Global Health
  • Business
  • Health
  • News
  • Science
  • Technology
  • +1 718 874 1545
  • +91 78878 22626
  • [email protected]
Office Address
Prudour Pvt. Ltd. 420 Lexington Avenue Suite 300 New York City, NY 10170.

Powered by Prudour Network

Copyrights © 2025 · Medical Market Report. All Rights Reserved.

Go to mobile version